Ultrasound Guided Knee Injections for Arthritis and Joint Pain Relief - Manchester
Knee Arthritis can be extremely painful and affect your daily activities. We provide ultrasound guided Knee injections for pain relief.
Delivered by a GMC-registered doctor under ultrasound guidance. No GP referral required.
CQC Regulated Clinic
Ultrasound Guided Procedure
No GP Referral Required
Manchester and Burnley Clinic
INTRO
Expert Knee Injection Treatment for Lasting Pain Relief
Chronic knee pain from arthritis can turn everyday activities, such as climbing stairs, walking to the shops, even standing up from a chair, into exhausting ordeals. If conservative approaches like physical therapy and anti-inflammatory medication have stopped delivering adequate symptom relief, knee injections offer a proven, minimally invasive treatment that delivers medication directly into the knee joint to reduce pain, control inflammation, and improve mobility without surgery.
At My MSK Clinic, we provide a range of targeted joint injections for patients living with osteoarthritis, rheumatoid arthritis, inflammatory arthritis, and other conditions causing pain and stiffness in the knee. Whether you need rapid relief from an acute flare or long term relief lasting up to five years, our specialist will identify the right injection for your situation and get you moving again.
WHY MY MSK
Why Choose My MSK Clinic for Knee Injections?
Ultrasound Accuracy
At My MSK all our injections are done under Ultrasound Guidance to make them as accurate as possible.
Same Day Option
Diagnosis and Injections can usually be done at the same appointment.
No Waiting List
You can Self Refer directly to MyMSK Clinic – No Referral required.
THE CONDITION
Understanding Knee Pain and Arthritis?
Arthritis is a broad term for inflammation of the joints. When it affects the knee, where the thigh bone meets the shin bone, it causes pain, swelling, stiffness, and progressive loss of movement that worsens over time.
There are two types of arthritis that present most commonly; Osteoarthritis and Rheumatoid Arthritis.
Knee Osteoarthritis
Knee osteoarthritis is the most common form. It is a degenerative condition affecting cartilage, which is the smooth, protective tissue that allows the bones in your knee joint to glide against each other. As this cartilage wears down, the bones begin grinding together, causing pain and disability. Cartilage wear is graded from 0 to 4, with 4 being full loss of cartilage (bone-on-bone contact).
Knee osteoarthritis can be caused by genetics, age, and injury, and obesity increases the risk of developing knee osteoarthritis. Symptoms include pain, stiffness, and loss of movement, typically worsening with use, for example walking up or down the stairs becomes harder, walks get shorter, and morning stiffness becomes a daily reality.
Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune condition where the body’s immune system attacks the synovial lining of the joint. This leads to chronic inflammation, cartilage destruction, and bone damage, often with symmetrical joint involvement and systemic symptoms.
In both cases, knee osteoarthritis symptoms tend to progress. Early-stage discomfort during activity can advance to moderate arthritis with persistent pain, and eventually to severe arthritis where basic daily tasks become genuinely difficult.
Understanding which stage you’re at, and what type of arthritis you have, determines which treatment approach will be most effective.
YOUR OPTIONS
Knee Injections We Offer at My MSK Clinic
We offer several injection types for different stages of knee arthritis, each with distinct mechanisms, timelines, and benefits. Knee injections are used to treat pain, inflammation, and stiffness, and injections are commonly considered when conservative treatments fail. Importantly, knee injections can potentially delay the need for knee replacement surgery, giving patients months or years of improved function.
All injections for knee conditions at our clinic are performed under ultrasound guidance with local anaesthetic for comfort.
Arthrosamid Injection
Arthrosamid is one of our most powerful injections for Knee arthritis related pain. For patients who want longer lasting relief from a single treatment, we offer a polyacrylamide hydrogel that works differently to lubricating injections, rather than temporarily topping up the joint fluid, it integrates into the lining of the knee as a cushioning support.
Clinical studies have reported benefits lasting up to five years, and it’s an option worth discussing if steroid or hyaluronic acid injections haven’t given you enough relief. Our Doctor assesses each knee to see if arthrosamid is a good option.
Book a consultation to see if Arthrosamid is suitable for you.
Durolane Injection
If your knee pain comes from the joint losing its natural lubrication, a single dose of high molecular weight hyaluronic acid can restore cushioning and ease movement without a series of weekly visits.
Many patients find the relief lasts considerably longer than standard gel injections, often well beyond six months. It tends to suit mild to moderate arthritis, so an ultrasound assessment first is important to confirm your knee is at the right stage to benefit.
The injection itself takes only a few minutes, and most patients walk out of the clinic and carry on with their day
Book a consultation to see if Durolane is suitable for you. Read our guide to see the costs involved.
Hyaluronic Acid
Hyaluronic acid occurs naturally in the synovial fluid of your knee joint, acting as a lubricating fluid and shock absorber. In osteoarthritis, this joint fluid degrades, the knee loses its natural cushioning.
Hyaluronic acid injections restore lubrication in the knee and may provide modest pain relief and improve movement. Research suggests that high molecular weight HA preparations produce better and longer lasting results than lower molecular weight alternatives.
Book a consultation to see if a Hyaluronic Acid injection is suitable for you.
Cortisone Injection
Steroid Injections (corticosteroid injections) are one of the most established joint injections. They work by delivering a potent anti-inflammatory steroid directly into the knee joint to rapidly reduce inflammation and relieve pain, often within days. Corticosteroid injections reduce inflammation in the knee joint effectively during acute flares.
Corticosteroid injections can provide relief for several weeks to a few months, with patients experiencing meaningful benefit for approximately 6–12 months.Â
Book a consultation to see if a Cortisone Injection is suitable for you. Read our guide to see the costs involved.
WHAT TO EXPECT
How Knee Injection Treatment Works
Step 1: Comprehensive Assessment
Your consultation begins with a thorough review of your medical history, family history, current symptoms, previous treatments, and lifestyle demands. Your specialist will examine your knee, assess joint mechanics and alignment, and may arrange imaging – typically X-ray to determine the grade of cartilage loss, or MRI if further detail is needed.
This assessment determines your arthritis type and severity, whether you’re a good candidate for injections, and which specific injection will deliver the best outcome for your situation.
Step 2: The Injection Procedure
The procedure for a knee injection at My MSK usually takes approximately 20–30 minutes including preparation. Your skin is cleaned with sterile technique, and a local anaesthetic numbs the injection site. Using real time ultrasound guidance, your specialist positions the needle precisely within the knee joint and delivers the medication. For hydrogel injections like Arthrosamid, the viscous material requires careful, controlled delivery. Most patients describe mild pressure rather than significant discomfort during the procedure.
Step 3: Recovery and Follow-up
You’ll be discharged the same day. After a Knee Injections many patients drive themselves home once they feel comfortable. In the first 24–48 hours, some patients experience a temporary increase in pain or swelling at the injection site – this is a normal post-injection flare and settles quickly. Avoid heavy lifting and high impact activity for a few weeks following treatment.
When to expect improvement: Cortisone Injections typically provide relief within days. Hyaluronic acid injections can take a couple weeks to reach full effect. Arthrosamid patients usually notice meaningful changes around four weeks, with full integration continuing over three months. Your Doctor will advise the expected time for results during the consultation.
At My MSK we Personalise aftercare protocols, to ensure they are suitable for each separate individual.
TESTIMONIALS
Knee Injection Reviews
We’re proud of the outcomes we help our patients achieve. Below are some real testimonials from our Manchester patients.
These testimonials are all collected from our profile on Google.
COST
How Much Does a Knee Injection Cost in Manchester?
From
£290
Per Knee Injection
The Cost of Knee Injections vary across the UK. At My MSK Clinic we believe in a transparent pricing system. We offer multiple different types of Knee Injections at our clinics. These consist of Cortisone at £290, Hyaluronic Acid from £375 and also Arthrosamid which costs £2500 per knee.
If you are considering this treatment, book a consult with us at My MSK Injection Clinic Manchester. The Doctor will perform a thorough examination and suggest whether a Knee Injection is suitable for you. No GP Referral required.
What's Included in the Cost?
✔ Consultation with Dr Akhtar
✔ Ultrasound Scan and examination
✔ Local Anaesthetic to ensure Comfort throughout the Procedure
✔ Any on-the-day Medications
✔ The Knee Injection
OUR CLINICS
Knee Injections Near You
We treat patients at two clinics in the North West. Easy to reach for Greater Manchester, Salford, Bury, Bolton, Oldham and the wider Lancashire area.
Knee Injections in Manchester
If you’re dealing with ongoing knee pain due to osteoarthritis, our Manchester clinic is here to help with knee injections, a trusted, non surgical solution for joint pain relief.
My MSK Clinic is dedicated to providing you with a comfortable, supportive, and seamless treatment experience from start to finish. At your visit, you’ll receive a full consultation and professional assessment, where we take the time to understand your specific symptoms and health history.
At MyMSK Clinic we often see patients travelling from across Lancashire. Our clinic is accessible to patients from Stockport. Cheadle, Altrincham, Wilsmow, etc. We also offer Durolane injections at our Burnley Clinic.
We treat patients from across Greater Manchester and the surrounding regions, including:
Manchester City Centre
Salford and Trafford
Stockport and Cheadle
Bolton, Bury, and Rochdale
Oldham and Tameside
Wigan and Leigh
Altrincham and Sale
Sheffield
Leeds
Liverpool
Wilmslow
Surrounding areas across the North West
Our clinic is easily accessible by public transport and has nearby parking for those driving.
FAQs
Frequently Asked Questions
How long do knee injections last?
Duration depends on the injection type and your individual factors:
Cortisone injections: Typically last around 6-12 Months. Relief may be shorter with repeated use.
Hyaluronic acid (Durolane): Around 6 – 12 months from a single dose, though observational data shows many patients going approximately 15 months before needing a subsequent injection.
Arthrosamid: Arthrosamid injections can last up to five years, with clinical studies demonstrating sustained benefit through 3–5 years.
What are the risks and side effects of Knee Injections?
Common risks of all knee injections include infection and allergic reaction, though both are rare with proper sterile technique.
Cortisone: Possible risks include cartilage degradation with repeated use, soft tissue atrophy, skin depigmentation at the injection site, and a temporary increase in blood sugar (particularly relevant for diabetic patients). At My MSK Clinic your doctor will review your past medical history to try and ensure the injection is safe as possible before proceeding.
Hyaluronic acid: Generally very well tolerated. Mild local pain, swelling, or a transient flare may occur. Serious adverse events are rare across safety reviews of over 8,000 patients.
Arthrosamid: Mostly mild to moderate localised reactions – swelling and tenderness – which resolve.
How do I know which injection is right for me?
Your specialist determines the best approach based on several factors: your arthritis type and stage (mild, moderate, or advanced arthritis), age, BMI, activity demands, previous response to other injections and other treatments, and your goals, whether you need rapid relief from a flare or long term relief from a single treatment.
For example, a patient with moderate arthritis who hasn’t responded to NSAIDs and wants fewer clinic visits might be an excellent candidate for Durolane.
Someone with more severe knee osteoarthritis looking for lasting results from a non surgical treatment might benefit most from Arthrosamid.
A patient in acute pain needing immediate relief to begin rehabilitation would likely start with cortisone.
How much Do Knee Injections Cost?
The cost of a knee injection depends on the type of injection. For example at My MSK Clinic an ultrasound Guided Cortisone Knee Injection costs £290.
A Durolane Injection, is a more powerful injection and usually provides longer pain relief. An ultrasound Guided Durolane injection costs £425.
For more information please head over to our Pricing Page or contact us.
Considering a Knee Injection in Manchester?
Ultrasound-guided. No GP referral needed. 7 minutes from Manchester Piccadilly.
PAGE MEDICALLY REVIEWED BY DR AMIR AKHTAR JULY 2026
Dr Amir Akhtar
Our Reviews









































































certification
GMC Registered Doctor and CQC Regulated Clinic



